Assay Detail
Functional
CHEMBL938421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.69 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 6.92 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.16 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.85 |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | 5.68 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.55 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 5.33 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 5.16 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.84 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | - |
| CHEMBL406254 | — | — | 1 | - |
| CHEMBL1129 | TRIFLURIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL318153 | EDOXUDINE | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL788 | IDOXURIDINE | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1090 | VIDARABINE | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL666 | FOSCARNET | EC50 | = | 250000.0 | nM | - |
| CHEMBL406254 | — | EC50 | = | 330000.0 | nM | - |
| CHEMBL1129 | TRIFLURIDINE | EC50 | < | 1700.0 | nM | - |