Assay Detail
Binding
CHEMBL938423
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Inhibition of Saccharomyces cerevisiae GGPPS
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl pyrophosphate synthase BTS1 (CHEMBL1075251) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.82 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192017 | — | — | 1 | 7.52 |
| CHEMBL262616 | — | — | 1 | 7.16 |
| CHEMBL213490 | — | — | 1 | 7.16 |
| CHEMBL260880 | — | — | 1 | 6.85 |
| CHEMBL259026 | — | — | 1 | 6.70 |
| CHEMBL411274 | — | — | 1 | 6.55 |
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 6.47 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192017 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL262616 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL213490 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL260880 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL259026 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL411274 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 660.0 | nM | 6.18 |