Assay Detail
Functional
CHEMBL938487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by High content screening
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.27 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507529 | — | — | 1 | 5.61 |
| CHEMBL496337 | — | — | 1 | 5.44 |
| CHEMBL498191 | — | — | 1 | 5.24 |
| CHEMBL498190 | — | — | 1 | 5.04 |
| CHEMBL525911 | — | — | 1 | 5.03 |
| CHEMBL478028 | — | — | 1 | - |
| CHEMBL484473 | — | — | 1 | - |
| CHEMBL497167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507529 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL496337 | — | EC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL498191 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL498190 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL525911 | — | EC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL478028 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL484473 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL497167 | — | EC50 | > | 20000.0 | nM | - |