Assay Detail
Binding
CHEMBL938685
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Inhibition of DPP9
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.52 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472128 | — | — | 1 | 8.34 |
| CHEMBL471547 | — | — | 1 | 8.20 |
| CHEMBL471731 | — | — | 1 | 7.60 |
| CHEMBL471546 | — | — | 1 | 7.46 |
| CHEMBL518144 | — | — | 1 | 7.09 |
| CHEMBL481466 | — | — | 1 | 7.06 |
| CHEMBL461912 | — | — | 1 | 6.93 |
| CHEMBL471544 | — | — | 1 | 6.67 |
| CHEMBL397070 | — | — | 1 | 6.54 |
| CHEMBL488226 | — | — | 1 | 6.30 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 6.17 |
| CHEMBL461092 | — | — | 1 | 5.85 |
| CHEMBL453573 | — | — | 1 | 5.68 |
| CHEMBL459642 | — | — | 1 | 5.55 |
| CHEMBL469890 | — | — | 1 | 5.37 |
| CHEMBL501126 | — | — | 1 | 5.29 |
| CHEMBL455298 | — | — | 1 | 5.29 |
| CHEMBL98408 | — | — | 1 | 5.18 |
| CHEMBL511659 | — | — | 1 | 5.04 |
| CHEMBL461289 | — | — | 1 | 4.96 |
| CHEMBL460886 | — | — | 1 | 4.95 |
| CHEMBL383705 | — | — | 1 | 4.95 |
| CHEMBL503274 | — | — | 1 | 4.86 |
| CHEMBL460065 | — | — | 1 | 4.84 |
| CHEMBL460885 | — | — | 1 | 4.80 |
| CHEMBL442952 | — | — | 1 | 4.80 |
| CHEMBL456298 | — | — | 1 | 4.58 |
| CHEMBL461506 | — | — | 1 | 4.55 |
| CHEMBL459438 | — | — | 1 | 4.47 |
| CHEMBL461291 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472128 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL471547 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL471731 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL471546 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL518144 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL481466 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL461912 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL471544 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL397070 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL488226 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL461092 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL453573 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL459642 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL469890 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL501126 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL455298 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL98408 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL511659 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL461289 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL460886 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL383705 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL503274 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL460065 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL442952 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL460885 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL456298 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL461506 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL459438 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL461291 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL460887 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL459159 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL453574 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL98869 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL83418 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL511346 | — | IC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL449318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL488227 | — | IC50 | - | — | - | |
| CHEMBL512705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL471747 | — | IC50 | - | — | - | |
| CHEMBL452470 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL510594 | — | IC50 | - | — | - | |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL443622 | — | IC50 | - | — | - | |
| CHEMBL97025 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL98008 | — | IC50 | - | — | - | |
| CHEMBL452029 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL455542 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL403882 | — | IC50 | - | — | - | |
| CHEMBL453918 | — | IC50 | - | — | - |