Assay Detail
Binding
CHEMBL938687
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Inhibition of DPP2
63
Total Activities
62
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.29 | 7.60 |
| Ki | 1 | 10.09 | 10.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98869 | — | — | 2 | 10.09 |
| CHEMBL518144 | — | — | 1 | 7.60 |
| CHEMBL472128 | — | — | 1 | 7.47 |
| CHEMBL481466 | — | — | 1 | 7.17 |
| CHEMBL510594 | — | — | 1 | 7.07 |
| CHEMBL471731 | — | — | 1 | 6.51 |
| CHEMBL471747 | — | — | 1 | 6.46 |
| CHEMBL461912 | — | — | 1 | 6.24 |
| CHEMBL471544 | — | — | 1 | 6.08 |
| CHEMBL461290 | — | — | 1 | 6.07 |
| CHEMBL461092 | — | — | 1 | 5.99 |
| CHEMBL501521 | — | — | 1 | 5.92 |
| CHEMBL461913 | — | — | 1 | 5.82 |
| CHEMBL461506 | — | — | 1 | 5.80 |
| CHEMBL488226 | — | — | 1 | 5.75 |
| CHEMBL488227 | — | — | 1 | 5.60 |
| CHEMBL455298 | — | — | 1 | 5.54 |
| CHEMBL461289 | — | — | 1 | 5.51 |
| CHEMBL460065 | — | — | 1 | 5.43 |
| CHEMBL456298 | — | — | 1 | 5.31 |
| CHEMBL459642 | — | — | 1 | 5.24 |
| CHEMBL459643 | — | — | 1 | 5.01 |
| CHEMBL501126 | — | — | 1 | 5.00 |
| CHEMBL511346 | — | — | 1 | 4.80 |
| CHEMBL459159 | — | — | 1 | 4.72 |
| CHEMBL471547 | — | — | 1 | 4.62 |
| CHEMBL98408 | — | — | 1 | 4.55 |
| CHEMBL397070 | — | — | 1 | 4.54 |
| CHEMBL460887 | — | — | 1 | 4.52 |
| CHEMBL471546 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98869 | — | Ki | = | 0.082 | nM | 10.09 |
| CHEMBL518144 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL472128 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL481466 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL510594 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL471731 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL471747 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL461912 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL471544 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL461290 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL461092 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL501521 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL461913 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL461506 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL488226 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL488227 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL455298 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL461289 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL460065 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL456298 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL459642 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL459643 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL501126 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL511346 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL459159 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL471547 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL98408 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL397070 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL460887 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL471546 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL98008 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL469890 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL460885 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL461911 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL452029 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL452470 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL83418 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL442952 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL459641 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL453918 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL511659 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL98869 | — | IC50 | < | 0.5 | nM | - |
| CHEMBL443622 | — | IC50 | = | 179000.0 | nM | - |
| CHEMBL403882 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL503274 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL453573 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL97025 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL383705 | — | IC50 | = | 153000.0 | nM | - |