Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL938997

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Güzel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT.
J Med Chem (2009) 52 : 4063 -4067
PubMed 19438226 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.89 9.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL521690 1 9.04
CHEMBL501294 1 9.03
CHEMBL468946 1 9.01
CHEMBL466234 1 9.01
CHEMBL468945 1 8.82
CHEMBL467898 1 8.49
CHEMBL511239 1 8.28
CHEMBL466832 1 8.19
CHEMBL468094 1 8.12
CHEMBL469126 1 8.03
CHEMBL468294 1 8.01
CHEMBL513854 1 7.68
CHEMBL467897 1 7.60
CHEMBL467258 1 7.50
CHEMBL513835 1 7.45
CHEMBL512633 1 7.32
CHEMBL77517 INDISULAM 2.0 1 7.01
CHEMBL6724 1 6.73
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.32
CHEMBL6633 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL521690 Ki = 0.92 nM 9.04
CHEMBL501294 Ki = 0.93 nM 9.03
CHEMBL468946 Ki = 0.97 nM 9.01
CHEMBL466234 Ki = 0.98 nM 9.01
CHEMBL468945 Ki = 1.5 nM 8.82
CHEMBL467898 Ki = 3.2 nM 8.49
CHEMBL511239 Ki = 5.2 nM 8.28
CHEMBL466832 Ki = 6.5 nM 8.19
CHEMBL468094 Ki = 7.6 nM 8.12
CHEMBL469126 Ki = 9.3 nM 8.03
CHEMBL468294 Ki = 9.7 nM 8.01
CHEMBL513854 Ki = 20.9 nM 7.68
CHEMBL467897 Ki = 25.1 nM 7.60
CHEMBL467258 Ki = 31.8 nM 7.50
CHEMBL513835 Ki = 35.3 nM 7.45
CHEMBL512633 Ki = 48.0 nM 7.32
CHEMBL77517 INDISULAM Ki = 97.0 nM 7.01
CHEMBL6724 Ki = 186.0 nM 6.73
CHEMBL20 ACETAZOLAMIDE Ki = 481.0 nM 6.32
CHEMBL6633 Ki = 750.0 nM 6.12