Assay Detail
Binding
CHEMBL939179
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Displacement of [125I]T3 from human TRalpha receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.76 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 10.24 |
| CHEMBL263630 | — | — | 1 | 8.92 |
| CHEMBL264153 | — | — | 1 | 7.82 |
| CHEMBL263631 | — | — | 1 | 7.77 |
| CHEMBL259096 | — | — | 1 | 7.62 |
| CHEMBL260482 | — | — | 1 | 7.60 |
| CHEMBL264152 | — | — | 1 | 7.38 |
| CHEMBL258886 | — | — | 1 | 7.37 |
| CHEMBL264410 | — | — | 1 | 7.09 |
| CHEMBL407819 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | Kd | = | 0.058 | nM | 10.24 |
| CHEMBL263630 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL264153 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL263631 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL259096 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL260482 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL264152 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL258886 | — | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL264410 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL407819 | — | Kd | = | 1700.0 | nM | 5.77 |