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Assay Detail

CHEMBL939298

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Binding
Inhibition of Escherichia coli OPPS
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH.
Proc Natl Acad Sci U S A (2007) 104 : 10022 -10027
PubMed 17535895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.44 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL192017 1 7.70
CHEMBL4303669 ZOLEDRONIC ACID 4.0 1 7.42
CHEMBL923 RISEDRONIC ACID 4.0 1 7.42
CHEMBL260880 1 7.12
CHEMBL213490 1 6.37
CHEMBL319144 MINODRONIC ACID 4.0 1 5.68
CHEMBL259026 1 5.27
CHEMBL411274 1 4.50
CHEMBL262616 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL192017 IC50 = 20.0 nM 7.70
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 38.0 nM 7.42
CHEMBL923 RISEDRONIC ACID IC50 = 38.0 nM 7.42
CHEMBL260880 IC50 = 75.0 nM 7.12
CHEMBL213490 IC50 = 430.0 nM 6.37
CHEMBL319144 MINODRONIC ACID IC50 = 2100.0 nM 5.68
CHEMBL259026 IC50 = 5400.0 nM 5.27
CHEMBL411274 IC50 = 32000.0 nM 4.50
CHEMBL262616 IC50 = 870000.0 nM -