Assay Detail
Binding
CHEMBL939309
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Inhibition of Staphylococcus aureus sortase A
6
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Activation of inhibitors by sortase triggers irreversible modification of the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.33 | 4.80 |
| IC50 | 2 | 4.58 | 4.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264166 | — | — | 2 | 4.82 |
| CHEMBL407492 | — | — | 2 | 4.33 |
| CHEMBL405826 | — | — | 1 | 4.16 |
| CHEMBL406959 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264166 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL264166 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL407492 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL405826 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL407492 | — | Ki | = | 93200.0 | nM | 4.03 |
| CHEMBL406959 | — | Activity | - | — | - |