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Assay Detail

CHEMBL939311

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum 3D7 by reduced [3H]hypoxanthine uptake
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR, Schiehser GA, Jacobus DP, Fidock DA, Sacchettini JC.
J Biol Chem (2007) 282 : 25436 -25444
PubMed 17567585 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 5.28 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261708 1 5.80
CHEMBL259403 1 5.70
CHEMBL261521 1 5.70
CHEMBL260979 1 5.68
CHEMBL258772 1 5.64
CHEMBL263896 1 5.60
CHEMBL261709 1 5.58
CHEMBL849 TRICLOSAN 4.0 1 5.55
CHEMBL408744 1 5.54
CHEMBL428260 1 5.47
CHEMBL405402 1 5.46
CHEMBL260978 1 5.46
CHEMBL260753 1 5.34
CHEMBL260061 1 5.25
CHEMBL259880 1 5.19
CHEMBL260600 1 5.16
CHEMBL428966 1 5.13
CHEMBL261144 1 5.13
CHEMBL260585 1 5.12
CHEMBL258736 1 5.09
CHEMBL258569 1 5.00
CHEMBL405973 1 4.96
CHEMBL258523 1 4.96
CHEMBL260168 1 4.72
CHEMBL258737 1 4.64
CHEMBL260375 1 4.40
CHEMBL240808 1 -
CHEMBL259734 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261708 EC50 = 1600.0 nM 5.80
CHEMBL259403 EC50 = 2000.0 nM 5.70
CHEMBL261521 EC50 = 2000.0 nM 5.70
CHEMBL260979 EC50 = 2100.0 nM 5.68
CHEMBL258772 EC50 = 2300.0 nM 5.64
CHEMBL263896 EC50 = 2500.0 nM 5.60
CHEMBL261709 EC50 = 2600.0 nM 5.58
CHEMBL849 TRICLOSAN EC50 = 2800.0 nM 5.55
CHEMBL408744 EC50 = 2900.0 nM 5.54
CHEMBL428260 EC50 = 3400.0 nM 5.47
CHEMBL405402 EC50 = 3500.0 nM 5.46
CHEMBL260978 EC50 = 3500.0 nM 5.46
CHEMBL260753 EC50 = 4600.0 nM 5.34
CHEMBL260061 EC50 = 5600.0 nM 5.25
CHEMBL259880 EC50 = 6400.0 nM 5.19
CHEMBL260600 EC50 = 6900.0 nM 5.16
CHEMBL428966 EC50 = 7400.0 nM 5.13
CHEMBL261144 EC50 = 7400.0 nM 5.13
CHEMBL260585 EC50 = 7500.0 nM 5.12
CHEMBL258736 EC50 = 8100.0 nM 5.09
CHEMBL258569 EC50 = 10000.0 nM 5.00
CHEMBL405973 EC50 = 11000.0 nM 4.96
CHEMBL258523 EC50 = 11000.0 nM 4.96
CHEMBL260168 EC50 = 19000.0 nM 4.72
CHEMBL258737 EC50 = 23000.0 nM 4.64
CHEMBL260375 EC50 = 40000.0 nM 4.40
CHEMBL240808 EC50 > 100000.0 nM -
CHEMBL259734 EC50 > 100000.0 nM -