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Compound Detail

CHEMBL259880

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Oc1cc(CCCc2ccccc2)ccc1Oc1ccc(Cl)cc1Cl

Basic Information

ChEMBL ID CHEMBL259880
Phase Preclinical
Structure Type MOL
InChI Key MJRPBNSOVIMDHN-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

373.3
MW (Da)
6.67
ALogP
2
HBA
1
HBD
29.5
PSA (Ų)
0.52
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H18Cl2O2
MW 373.28
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -0.17

Activity Summary

EC50 2 meas. best 5.19
IC50 2 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycobacterium tuberculosis
CHEMBL360
IC50 7.3 7.3 50.0 1
Enoyl-acyl-carrier protein reductase
CHEMBL4150
IC50 6.36 6.36 440.0 1
Plasmodium falciparum
CHEMBL364
EC50 5.19 5.165 6400.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17567585 10.1074/jbc.m701813200 Plasmodium falciparum 2
20727773 10.1016/j.bmc.2010.07.010 Mycobacterium tuberculosis 2
17567585 10.1074/jbc.m701813200 Enoyl-acyl-carrier protein reductase 1

Data from ChEMBL 36 via Core Engine