Assay Detail
Binding
CHEMBL939353
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Inhibition of ERK1
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.42 | 4.70 |
| Ki | 1 | 6.51 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259551 | — | — | 1 | 6.51 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 4.70 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.47 |
| CHEMBL404939 | — | — | 1 | 4.08 |
| CHEMBL406375 | — | — | 1 | - |
| CHEMBL261237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259551 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL404939 | — | IC50 | = | 82900.0 | nM | 4.08 |
| CHEMBL406375 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL261237 | — | IC50 | > | 10000.0 | nM | - |