Compound Detail
CHEMBL406375
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Basic Information
| ChEMBL ID | CHEMBL406375 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DZQLVVLATXPWBK-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
234.3
MW (Da)
3.98
ALogP
2
HBA
1
HBD
41.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Histone deacetylase 6 CHEMBL1865 | IC50 | 5.71 | 5.71 | 1949.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 300.0 | nM | 6.52 | Inhibition of cFMS | 18077363 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 300.0 | nM | 6.52 | Inhibition of c-kit | 18077363 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 300.0 | nM | 6.52 | Inhibition of wild type FLT3 | 18077363 |
| Unchecked | IC50 | = | 300.0 | nM | 6.52 | Inhibition of FLT3 ITD mutant | 18077363 |
| Platelet-derived growth factor receptor beta | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of PDGFRbeta | 18077363 |
| Histone deacetylase 6 | IC50 | = | 1949.0 | nM | 5.71 | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 wi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18077363 | 10.1073/pnas.0708800104 | Unchecked | 4 |
| 23398362 | 10.1042/bj20121418 | Insulin-like growth factor 1 receptor | 4 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 4 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase mTOR | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase HCK | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase Lck | 4 |
| 23398362 | 10.1042/bj20121418 | Cyclin-dependent kinase 5/CDK5 activator 1 | 4 |
| 23398362 | 10.1042/bj20121418 | Insulin receptor | 4 |
| 23398362 | 10.1042/bj20121418 | cGMP-dependent protein kinase 1 | 4 |
| 23398362 | 10.1042/bj20121418 | Protein kinase C beta type | 4 |
| 23398362 | 10.1042/bj20121418 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | 2 |
| 23398362 | 10.1042/bj20121418 | Casein kinase I isoform delta | 2 |
| 23398362 | 10.1042/bj20121418 | Casein kinase I isoform gamma-3 | 2 |
| 23398362 | 10.1042/bj20121418 | SRSF protein kinase 3 | 2 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase MARK1 | 2 |
| 18077363 | 10.1073/pnas.0708800104 | Mitogen-activated protein kinase 3 | 2 |
| 23398362 | 10.1042/bj20121418 | Fibroblast growth factor receptor 4 | 2 |
| 23398362 | 10.1042/bj20121418 | Ephrin type-A receptor 5 | 2 |
| 23398362 | 10.1042/bj20121418 | Mitogen-activated protein kinase 10 | 2 |
| 23398362 | 10.1042/bj20121418 | Fibroblast growth factor receptor 3 | 2 |
Data from ChEMBL 36 via Core Engine