Assay Detail
Binding
CHEMBL939359
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Inhibition of PKCalpha
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.80 | 8.70 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302449 | GO-6976 | — | 1 | 8.70 |
| CHEMBL366266 | — | — | 1 | 6.48 |
| CHEMBL411901 | — | — | 1 | 5.21 |
| CHEMBL261644 | — | — | 1 | - |
| CHEMBL541643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302449 | GO-6976 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL366266 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL411901 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL261644 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL541643 | — | IC50 | >= | 3400.0 | nM | - |