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Assay Detail

CHEMBL939372

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Binding
Inhibition of Src
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Proto-oncogene tyrosine-protein kinase Src (CHEMBL267)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S.
Proc Natl Acad Sci U S A (2007) 104 : 20523 -20528
PubMed 18077363 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 6.09 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL605003 1 6.55
CHEMBL260138 ALSTERPAULLONE 2 1 6.50
CHEMBL1276317 1 6.37
CHEMBL258726 1 5.66
CHEMBL437612 1 5.36
CHEMBL406375 1 -
CHEMBL261238 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL605003 IC50 = 280.0 nM 6.55
CHEMBL260138 ALSTERPAULLONE 2 IC50 = 316.23 nM 6.50
CHEMBL1276317 IC50 = 430.0 nM 6.37
CHEMBL258726 IC50 = 2200.0 nM 5.66
CHEMBL437612 IC50 = 4400.0 nM 5.36
CHEMBL406375 IC50 >= 10000.0 nM -
CHEMBL261238 IC50 > 400000000.0 nM -