Assay Detail
Functional
CHEMBL939425
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Antiprotozoal activity against Plasmodium falciparum K1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.00 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145251 | — | — | 1 | 8.19 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.81 |
| CHEMBL261271 | — | — | 1 | 7.64 |
| CHEMBL407410 | — | — | 1 | 7.57 |
| CHEMBL259707 | — | — | 1 | 7.20 |
| CHEMBL259792 | — | — | 1 | 7.07 |
| CHEMBL405915 | — | — | 1 | 7.04 |
| CHEMBL259591 | — | — | 1 | 6.74 |
| CHEMBL261059 | — | — | 1 | 6.21 |
| CHEMBL259825 | — | — | 1 | 6.06 |
| CHEMBL259500 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145251 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL261271 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL407410 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL259707 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL259792 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL405915 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL259591 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL261059 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL259825 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL259500 | — | IC50 | = | 3249.0 | nM | 5.49 |