Assay Detail
Binding
CHEMBL939482
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Displacement of [3H]DPCPX form human adenosine A1 receptor expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.79 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401321 | — | — | 1 | 8.04 |
| CHEMBL251975 | — | — | 1 | 6.57 |
| CHEMBL270761 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401321 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL251975 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL270761 | — | Ki | = | 1700.0 | nM | 5.77 |