Assay Detail
Binding
CHEMBL939833
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Inhibition of Akt1 by cell based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447328 | — | — | 1 | 8.30 |
| CHEMBL502854 | — | — | 1 | 7.77 |
| CHEMBL508794 | — | — | 1 | 7.74 |
| CHEMBL499555 | — | — | 1 | 7.74 |
| CHEMBL445464 | — | — | 1 | 7.61 |
| CHEMBL506077 | — | — | 1 | 7.57 |
| CHEMBL442919 | — | — | 1 | 7.38 |
| CHEMBL446779 | — | — | 1 | 7.20 |
| CHEMBL508861 | — | — | 1 | 6.95 |
| CHEMBL509747 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447328 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL502854 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL508794 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL499555 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL445464 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL506077 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL442919 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL446779 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL508861 | — | IC50 | = | 113.5 | nM | 6.95 |
| CHEMBL509747 | — | IC50 | = | 265.5 | nM | 6.58 |