Assay Detail
Functional
CHEMBL939920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.32 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405519 | — | — | 1 | 9.19 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.40 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.37 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405519 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL53 | APOMORPHINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL59 | DOPAMINE | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL24077 | (R)-SKF-38393 | EC50 | > | 10000.0 | nM | - |