Assay Detail
Functional
CHEMBL940098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.00 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410304 | — | — | 1 | 9.89 |
| CHEMBL260538 | ULIPRISTAL ACETATE | 4.0 | 1 | 9.70 |
| CHEMBL267431 | ASOPRISNIL | 3.0 | 1 | 9.70 |
| CHEMBL410923 | — | — | 1 | 9.57 |
| CHEMBL259879 | — | — | 1 | 9.48 |
| CHEMBL411522 | — | — | 1 | 9.37 |
| CHEMBL258522 | — | — | 1 | 9.33 |
| CHEMBL260330 | — | — | 1 | 9.26 |
| CHEMBL260764 | — | — | 1 | 9.22 |
| CHEMBL409661 | — | — | 1 | 9.21 |
| CHEMBL260869 | — | — | 1 | 9.20 |
| CHEMBL408424 | — | — | 1 | 9.12 |
| CHEMBL407371 | — | — | 1 | 9.01 |
| CHEMBL411086 | — | — | 1 | 8.89 |
| CHEMBL409905 | — | — | 1 | 8.60 |
| CHEMBL268788 | — | — | 1 | 8.50 |
| CHEMBL411063 | — | — | 1 | 8.49 |
| CHEMBL438593 | — | — | 1 | 8.44 |
| CHEMBL406439 | — | — | 1 | 8.10 |
| CHEMBL258521 | — | — | 1 | 8.07 |
| CHEMBL261650 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410304 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL260538 | ULIPRISTAL ACETATE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL267431 | ASOPRISNIL | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL410923 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL259879 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL411522 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL258522 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL260330 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL260764 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL409661 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL260869 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL408424 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL407371 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL411086 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL409905 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL268788 | — | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL411063 | — | IC50 | = | 3.25 | nM | 8.49 |
| CHEMBL438593 | — | IC50 | = | 3.64 | nM | 8.44 |
| CHEMBL406439 | — | IC50 | = | 7.89 | nM | 8.10 |
| CHEMBL258521 | — | IC50 | = | 8.48 | nM | 8.07 |
| CHEMBL261650 | — | IC50 | = | 14.8 | nM | 7.83 |