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Assay Detail

CHEMBL940120

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 3B assessed as inhibition of virus-induced cytopathogenicity in MT4 cells after 4 days by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).
Lin Y, Liu X, Yan R, Li J, Pannecouque C, Witvrouw M, De Clercq E.
Bioorg Med Chem (2008) 16 : 157 -163
PubMed 17964796 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 5.87 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129 ZIDOVUDINE 4.0 1 9.15
CHEMBL57 NEVIRAPINE 4.0 1 7.52
CHEMBL133626 1 7.00
CHEMBL132150 1 6.05
CHEMBL259062 1 5.40
CHEMBL259160 1 5.32
CHEMBL258743 1 5.29
CHEMBL259179 1 5.23
CHEMBL411247 1 5.14
CHEMBL412305 1 4.28
CHEMBL261344 1 4.15
CHEMBL259159 1 -
CHEMBL260516 1 -
CHEMBL261590 1 -
CHEMBL264398 1 -
CHEMBL409724 1 -
CHEMBL410140 1 -
CHEMBL264673 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129 ZIDOVUDINE EC50 = 0.7 nM 9.15
CHEMBL57 NEVIRAPINE EC50 = 30.0 nM 7.52
CHEMBL133626 EC50 = 100.0 nM 7.00
CHEMBL132150 EC50 = 900.0 nM 6.05
CHEMBL259062 EC50 = 4000.0 nM 5.40
CHEMBL259160 EC50 = 4800.0 nM 5.32
CHEMBL258743 EC50 = 5100.0 nM 5.29
CHEMBL259179 EC50 = 5900.0 nM 5.23
CHEMBL411247 EC50 = 7300.0 nM 5.14
CHEMBL412305 EC50 = 52100.0 nM 4.28
CHEMBL261344 EC50 = 71000.0 nM 4.15
CHEMBL259159 EC50 > 37500.0 nM -
CHEMBL260516 EC50 > 373900.0 nM -
CHEMBL261590 EC50 > 8200.0 nM -
CHEMBL264398 EC50 > 6600.0 nM -
CHEMBL409724 EC50 > 8500.0 nM -
CHEMBL410140 EC50 > 268000.0 nM -
CHEMBL264673 EC50 > 5700.0 nM -