Assay Detail
Binding
CHEMBL940160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of TRPA1
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.43 | 7.00 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258455 | — | — | 1 | 7.00 |
| CHEMBL402589 | — | — | 1 | 6.10 |
| CHEMBL256738 | — | — | 1 | 5.80 |
| CHEMBL256368 | PENTENAL | — | 1 | 5.30 |
| CHEMBL721 | ACROLEIN | — | 1 | 5.30 |
| CHEMBL401514 | PROPARGYL ISOTHIOCYANATE | — | 1 | 4.74 |
| CHEMBL293492 | CINNAMALDEHYDE | -1.0 | 1 | 4.72 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | 1.0 | 1 | 4.47 |
| CHEMBL257362 | IODOACETAMIDE ALKYNE | — | 1 | - |
| CHEMBL276727 | IODOACETAMIDE | — | 1 | - |
| CHEMBL324794 | CINNAMIC ALCOHOL | — | 1 | - |
| CHEMBL275626 | PROPIONALDEHYDE | — | 1 | - |
| CHEMBL258012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258455 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL402589 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL256738 | — | EC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL256368 | PENTENAL | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL721 | ACROLEIN | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL401514 | PROPARGYL ISOTHIOCYANATE | EC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL293492 | CINNAMALDEHYDE | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | EC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL257362 | IODOACETAMIDE ALKYNE | EC50 | = | 134000.0 | nM | - |
| CHEMBL276727 | IODOACETAMIDE | EC50 | = | 357000.0 | nM | - |
| CHEMBL324794 | CINNAMIC ALCOHOL | Activity | - | — | - | |
| CHEMBL275626 | PROPIONALDEHYDE | Activity | - | — | - | |
| CHEMBL258012 | — | Activity | - | — | - |