Assay Detail
Binding
CHEMBL940221
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Inhibition of AChE
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.93 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.80 |
| CHEMBL259264 | — | — | 1 | 6.46 |
| CHEMBL259482 | — | — | 1 | 5.96 |
| CHEMBL129306 | — | — | 1 | 5.64 |
| CHEMBL129542 | JNJ-5207852 | — | 1 | 5.50 |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL259264 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL259482 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL129306 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL129542 | JNJ-5207852 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1190 | DECAMETHONIUM | IC50 | = | 5900.0 | nM | 5.23 |