Assay Detail
Binding
CHEMBL940222
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Inhibition of histamine H3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.15 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.28 |
| CHEMBL129306 | — | — | 1 | 9.14 |
| CHEMBL259264 | — | — | 1 | 9.01 |
| CHEMBL259482 | — | — | 1 | 8.89 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.46 |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL129306 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL259264 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL259482 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1190 | DECAMETHONIUM | IC50 | = | 820.0 | nM | 6.09 |