Assay Detail
Binding
CHEMBL940738
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Inhibition of PDE4B
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.57 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250137 | — | — | 1 | 9.30 |
| CHEMBL399385 | — | — | 1 | 9.00 |
| CHEMBL251107 | — | — | 1 | 9.00 |
| CHEMBL249933 | — | — | 1 | 8.92 |
| CHEMBL399298 | — | — | 1 | 8.85 |
| CHEMBL400976 | — | — | 1 | 8.80 |
| CHEMBL437020 | — | — | 1 | 8.70 |
| CHEMBL401345 | — | — | 1 | 8.66 |
| CHEMBL249691 | — | — | 1 | 8.37 |
| CHEMBL401121 | — | — | 1 | 7.77 |
| CHEMBL401186 | — | — | 1 | 7.72 |
| CHEMBL40200 | — | — | 1 | 7.70 |
| CHEMBL399690 | — | — | 1 | 7.62 |
| CHEMBL249486 | — | — | 1 | 7.51 |
| CHEMBL399297 | — | — | 1 | 7.31 |
| CHEMBL429484 | — | — | 1 | 7.28 |
| CHEMBL250546 | SCH-351591 | — | 1 | 7.22 |
| CHEMBL401120 | — | — | 1 | 7.21 |
| CHEMBL248683 | — | — | 1 | 7.12 |
| CHEMBL251712 | — | — | 1 | 7.10 |
| CHEMBL398454 | — | — | 1 | 7.06 |
| CHEMBL249285 | — | — | 1 | 6.96 |
| CHEMBL398254 | — | — | 1 | 6.51 |
| CHEMBL400079 | — | — | 1 | 6.46 |
| CHEMBL400276 | — | — | 1 | 6.41 |
| CHEMBL251299 | — | — | 1 | 6.33 |
| CHEMBL251298 | — | — | 1 | 6.33 |
| CHEMBL399898 | — | — | 1 | 6.24 |
| CHEMBL428415 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250137 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL399385 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL251107 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL249933 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL399298 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL400976 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL437020 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL401345 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL249691 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL401121 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL401186 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL40200 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL399690 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL249486 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL399297 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL429484 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL250546 | SCH-351591 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL401120 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL248683 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL251712 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL398454 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL249285 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL398254 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL400079 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL400276 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL251299 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL251298 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL399898 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL428415 | — | IC50 | = | 670.0 | nM | 6.17 |