Assay Detail
Binding
CHEMBL940816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tyrosinase in Melan-a cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Melan-a |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147069 | — | — | 1 | 5.31 |
| CHEMBL399354 | — | — | 1 | 4.84 |
| CHEMBL246622 | — | — | 1 | 4.82 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147069 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL399354 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL246622 | — | IC50 | = | 15210.0 | nM | 4.82 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 30260.0 | nM | 4.52 |