Assay Detail
Binding
CHEMBL940864
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Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.65 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247245 | — | — | 1 | 6.12 |
| CHEMBL246804 | — | — | 1 | 5.82 |
| CHEMBL247455 | — | — | 1 | 5.00 |
| CHEMBL248418 | — | — | 1 | - |
| CHEMBL398747 | — | — | 1 | - |
| CHEMBL392814 | — | — | 1 | - |
| CHEMBL247608 | — | — | 1 | - |
| CHEMBL393267 | — | — | 1 | - |
| CHEMBL247621 | — | — | 1 | - |
| CHEMBL400196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247245 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL246804 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL247455 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL248418 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL398747 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL392814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL247608 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL393267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL247621 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL400196 | — | IC50 | > | 10000.0 | nM | - |