Assay Detail
Binding
CHEMBL940954
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Inhibition of kinesin spindle protein by ATPase assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.46 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247044 | — | — | 1 | 9.70 |
| CHEMBL246603 | — | — | 1 | 8.92 |
| CHEMBL250125 | — | — | 1 | 8.80 |
| CHEMBL443490 | — | — | 1 | 8.70 |
| CHEMBL246604 | — | — | 1 | 8.68 |
| CHEMBL248400 | — | — | 1 | 8.42 |
| CHEMBL246422 | — | — | 1 | 8.42 |
| CHEMBL247414 | — | — | 1 | 8.41 |
| CHEMBL246000 | — | — | 1 | 8.40 |
| CHEMBL246001 | — | — | 1 | 8.38 |
| CHEMBL392599 | — | — | 1 | 8.33 |
| CHEMBL248244 | — | — | 1 | 8.28 |
| CHEMBL247594 | — | — | 1 | 8.00 |
| CHEMBL401006 | — | — | 1 | 7.78 |
| CHEMBL393647 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247044 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL246603 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL250125 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL443490 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL246604 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL248400 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL246422 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL247414 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL246000 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL246001 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL392599 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL248244 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL247594 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL401006 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL393647 | — | IC50 | = | 21.8 | nM | 7.66 |