Compound Detail
CHEMBL246604
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL246604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HBHHQROCMYJFKL-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
385.5
MW (Da)
4.01
ALogP
4
HBA
0
HBD
35.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.03
IC50 1 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kinesin-like protein KIF11 CHEMBL4581 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
| Kinesin-like protein KIF11 CHEMBL4581 | EC50 | 8.03 | 8.03 | 9.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kinesin-like protein KIF11 | IC50 | = | 2.1 | nM | 8.68 | Inhibition of kinesin spindle protein by ATPase assay | 17766111 |
| Kinesin-like protein KIF11 | EC50 | = | 9.4 | nM | 8.03 | Inhibition of KSP-induced nucleolin phosphorylation in cell-based mitotic arrest... | 17766111 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17766111 | 10.1016/j.bmcl.2007.07.074 | Kinesin-like protein KIF11 | 2 |
Data from ChEMBL 36 via Core Engine