Assay Detail
Binding
CHEMBL940963
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Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.24 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398431 | — | — | 1 | 9.10 |
| CHEMBL249071 | — | — | 1 | 8.42 |
| CHEMBL249070 | — | — | 1 | 8.15 |
| CHEMBL9337 | RU-58841 | — | 1 | 7.80 |
| CHEMBL248690 | — | — | 1 | 7.70 |
| CHEMBL249072 | — | — | 1 | 7.14 |
| CHEMBL248868 | — | — | 1 | 7.11 |
| CHEMBL399876 | — | — | 1 | 6.91 |
| CHEMBL248841 | — | — | 1 | 6.77 |
| CHEMBL398432 | — | — | 1 | 6.68 |
| CHEMBL400098 | — | — | 1 | 5.77 |
| CHEMBL248878 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398431 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL249071 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL249070 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL9337 | RU-58841 | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL248690 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL249072 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL248868 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL399876 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL248841 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL398432 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL400098 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL248878 | — | IC50 | = | 4926.0 | nM | 5.31 |