Assay Detail
Functional
CHEMBL940964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.89 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9337 | RU-58841 | — | 1 | 7.51 |
| CHEMBL248690 | — | — | 1 | 7.35 |
| CHEMBL249072 | — | — | 1 | 6.87 |
| CHEMBL399876 | — | — | 1 | 6.64 |
| CHEMBL248841 | — | — | 1 | 6.58 |
| CHEMBL398432 | — | — | 1 | 6.38 |
| CHEMBL248868 | — | — | 1 | - |
| CHEMBL400098 | — | — | 1 | - |
| CHEMBL249071 | — | — | 1 | - |
| CHEMBL249070 | — | — | 1 | - |
| CHEMBL398431 | — | — | 1 | - |
| CHEMBL248878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9337 | RU-58841 | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL248690 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL249072 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL399876 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL248841 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL398432 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL248868 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL400098 | — | IC50 | - | — | - | |
| CHEMBL249071 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL249070 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL398431 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL248878 | — | IC50 | - | — | - |