Assay Detail
Functional
CHEMBL941164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus Pig1 isolate after 72 hrs
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.66 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489113 | — | — | 1 | 7.96 |
| CHEMBL522608 | — | — | 1 | 7.82 |
| CHEMBL490300 | — | — | 1 | 7.82 |
| CHEMBL160318 | — | — | 1 | 7.72 |
| CHEMBL473742 | — | — | 1 | 7.68 |
| CHEMBL473741 | — | — | 1 | 7.41 |
| CHEMBL460912 | — | — | 1 | 7.40 |
| CHEMBL514788 | — | — | 1 | 7.31 |
| CHEMBL460718 | — | — | 1 | 7.30 |
| CHEMBL490690 | — | — | 1 | 7.29 |
| CHEMBL461778 | — | — | 1 | 7.28 |
| CHEMBL490890 | — | — | 1 | 7.23 |
| CHEMBL473344 | — | — | 1 | 7.13 |
| CHEMBL160340 | — | — | 1 | 7.03 |
| CHEMBL491874 | — | — | 1 | 7.00 |
| CHEMBL351151 | — | — | 1 | 6.96 |
| CHEMBL499922 | — | — | 1 | 6.96 |
| CHEMBL158844 | — | — | 1 | 6.80 |
| CHEMBL473739 | — | — | 1 | 6.77 |
| CHEMBL516975 | — | — | 1 | 6.75 |
| CHEMBL160284 | — | — | 1 | 6.75 |
| CHEMBL516044 | — | — | 1 | 6.72 |
| CHEMBL473343 | — | — | 1 | 6.66 |
| CHEMBL462651 | — | — | 1 | 6.51 |
| CHEMBL513790 | — | — | 1 | 6.46 |
| CHEMBL474135 | — | — | 1 | 6.34 |
| CHEMBL461788 | — | — | 1 | 6.31 |
| CHEMBL473738 | — | — | 1 | 6.30 |
| CHEMBL515716 | — | — | 1 | 6.29 |
| CHEMBL491875 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489113 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL522608 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL490300 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL160318 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL473742 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL473741 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL460912 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL514788 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL460718 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL490690 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL461778 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL490890 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL473344 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL160340 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL491874 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL351151 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL499922 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL158844 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL473739 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL516975 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL160284 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL516044 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL473343 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL462651 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL513790 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL474135 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL461788 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL473738 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL515716 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL491875 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL460896 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL513622 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL460895 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL490494 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL473937 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL473737 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL461965 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL473934 | — | IC50 | = | 263000.0 | nM | - |