Assay Detail
Binding
CHEMBL941183
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Inhibition of human C-terminal His-tagged AdoMetDC assessed as release of 14CO2 from S-adenosyl-L-[carboxy-14C]methionine
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
S-adenosylmethionine decarboxylase proenzyme (CHEMBL4181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517131 | — | — | 1 | 8.30 |
| CHEMBL510356 | — | — | 1 | 8.15 |
| CHEMBL461970 | — | — | 1 | 7.96 |
| CHEMBL461779 | — | — | 1 | 7.82 |
| CHEMBL516811 | — | — | 1 | 7.75 |
| CHEMBL460719 | — | — | 1 | 7.31 |
| CHEMBL461780 | — | — | 1 | 7.26 |
| CHEMBL453372 | — | — | 1 | 7.07 |
| CHEMBL517593 | — | — | 1 | 6.77 |
| CHEMBL462656 | — | — | 1 | 6.40 |
| CHEMBL516214 | — | — | 1 | 6.22 |
| CHEMBL462138 | — | — | 1 | 5.82 |
| CHEMBL473134 | — | — | 1 | 5.52 |
| CHEMBL517908 | — | — | 1 | 5.40 |
| CHEMBL473336 | — | — | 1 | 5.30 |
| CHEMBL461969 | — | — | 1 | 5.16 |
| CHEMBL472733 | — | — | 1 | 5.05 |
| CHEMBL462139 | — | — | 1 | 4.51 |
| CHEMBL515862 | — | — | 1 | 4.16 |
| CHEMBL462660 | — | — | 1 | 4.06 |
| CHEMBL474137 | — | — | 1 | - |
| CHEMBL472730 | — | — | 1 | - |
| CHEMBL460737 | — | — | 1 | - |
| CHEMBL461966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517131 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL510356 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL461970 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL461779 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL516811 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL460719 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL461780 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL453372 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL517593 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL462656 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL516214 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL462138 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL473134 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL517908 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL473336 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL461969 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL472733 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL462139 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL515862 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL462660 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL474137 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL472730 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL460737 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL461966 | — | IC50 | = | 440000.0 | nM | - |