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Assay Detail

CHEMBL941536

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX1
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.
Kang SS, Cuendet M, Endringer DC, Croy VL, Pezzuto JM, Lipton MA.
Bioorg Med Chem (2009) 17 : 1044 -1054
PubMed 18487053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 5.22 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL513053 1 6.77
CHEMBL473518 RHAPONTIGENIN 1 6.54
CHEMBL83527 PTEROSTILBENE 2.0 1 6.16
CHEMBL165 RESVERATROL 3.0 1 6.08
CHEMBL474128 1 6.01
CHEMBL449735 1 6.00
CHEMBL474127 1 5.72
CHEMBL491080 1 5.72
CHEMBL490673 1 5.66
CHEMBL446586 1 5.52
CHEMBL452888 1 5.50
CHEMBL471103 1 5.46
CHEMBL468886 1 5.31
CHEMBL475539 1 5.28
CHEMBL489283 1 5.27
CHEMBL470938 1 5.13
CHEMBL474731 1 5.11
CHEMBL522423 1 5.01
CHEMBL210300 1 5.00
CHEMBL510069 1 4.98
CHEMBL491081 1 4.97
CHEMBL489489 1 4.97
CHEMBL489093 1 4.96
CHEMBL475135 1 4.94
CHEMBL464755 1 4.94
CHEMBL470940 1 4.94
CHEMBL474935 1 4.91
CHEMBL490482 1 4.78
CHEMBL490674 1 4.75
CHEMBL487587 1 4.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL513053 IC50 = 170.0 nM 6.77
CHEMBL473518 RHAPONTIGENIN IC50 = 290.0 nM 6.54
CHEMBL83527 PTEROSTILBENE IC50 = 700.0 nM 6.16
CHEMBL165 RESVERATROL IC50 = 830.0 nM 6.08
CHEMBL474128 IC50 = 970.0 nM 6.01
CHEMBL449735 IC50 = 990.0 nM 6.00
CHEMBL474127 IC50 = 1900.0 nM 5.72
CHEMBL491080 IC50 = 1900.0 nM 5.72
CHEMBL490673 IC50 = 2200.0 nM 5.66
CHEMBL446586 IC50 = 3000.0 nM 5.52
CHEMBL452888 IC50 = 3200.0 nM 5.50
CHEMBL471103 IC50 = 3500.0 nM 5.46
CHEMBL468886 IC50 = 4900.0 nM 5.31
CHEMBL475539 IC50 = 5300.0 nM 5.28
CHEMBL489283 IC50 = 5400.0 nM 5.27
CHEMBL470938 IC50 = 7400.0 nM 5.13
CHEMBL474731 IC50 = 7800.0 nM 5.11
CHEMBL522423 IC50 = 9700.0 nM 5.01
CHEMBL210300 IC50 = 10000.0 nM 5.00
CHEMBL510069 IC50 = 10500.0 nM 4.98
CHEMBL491081 IC50 = 10600.0 nM 4.97
CHEMBL489489 IC50 = 10700.0 nM 4.97
CHEMBL489093 IC50 = 10900.0 nM 4.96
CHEMBL475135 IC50 = 11400.0 nM 4.94
CHEMBL464755 IC50 = 11500.0 nM 4.94
CHEMBL470940 IC50 = 11600.0 nM 4.94
CHEMBL474935 IC50 = 12400.0 nM 4.91
CHEMBL490482 IC50 = 16500.0 nM 4.78
CHEMBL490674 IC50 = 17800.0 nM 4.75
CHEMBL487587 IC50 = 18400.0 nM 4.74
CHEMBL291501 RESVERATROL 4'-METHYL ETHER IC50 = 25800.0 nM 4.59
CHEMBL490483 IC50 = 29700.0 nM 4.53
CHEMBL471104 IC50 = 30500.0 nM 4.52
CHEMBL505264 IC50 = 32600.0 nM 4.49
CHEMBL491079 IC50 = 36300.0 nM 4.44
CHEMBL451311 IC50 = 51300.0 nM 4.29