Assay Detail
Functional
CHEMBL941578
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Antiproliferative activity against human HCT116 cells after 3 days by methylene blue stain technique
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thiophene inhibitors of polo-like kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.53 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514499 | GW843682X | — | 1 | 6.16 |
| CHEMBL474028 | — | — | 1 | 6.03 |
| CHEMBL514162 | GW852849X | — | 1 | 6.00 |
| CHEMBL475857 | — | — | 1 | 5.96 |
| CHEMBL474053 | — | — | 1 | 5.94 |
| CHEMBL474843 | — | — | 1 | 5.91 |
| CHEMBL480545 | — | — | 1 | 5.83 |
| CHEMBL480383 | — | — | 1 | 5.82 |
| CHEMBL480382 | GSK-312948A | — | 1 | 5.81 |
| CHEMBL519120 | — | — | 1 | 5.77 |
| CHEMBL475763 | — | — | 1 | 5.75 |
| CHEMBL474054 | — | — | 1 | 5.68 |
| CHEMBL475783 | — | — | 1 | 5.64 |
| CHEMBL514634 | — | — | 1 | 5.58 |
| CHEMBL474029 | — | — | 1 | 5.58 |
| CHEMBL514968 | — | — | 1 | 5.57 |
| CHEMBL514826 | — | — | 1 | 5.53 |
| CHEMBL520080 | — | — | 1 | 5.51 |
| CHEMBL473630 | — | — | 1 | 5.47 |
| CHEMBL475616 | — | — | 1 | 5.46 |
| CHEMBL481510 | GW853606X | — | 1 | 5.45 |
| CHEMBL475215 | — | — | 1 | 5.26 |
| CHEMBL474432 | — | — | 1 | 5.12 |
| CHEMBL516362 | — | — | 1 | 5.11 |
| CHEMBL514643 | — | — | 1 | 4.92 |
| CHEMBL519286 | — | — | 1 | 4.72 |
| CHEMBL475762 | — | — | 1 | 4.68 |
| CHEMBL473629 | GSK-204925A | — | 1 | 4.62 |
| CHEMBL481492 | — | — | 1 | - |
| CHEMBL519289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514499 | GW843682X | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL474028 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL514162 | GW852849X | IC50 | = | 999.0 | nM | 6.00 |
| CHEMBL475857 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL474053 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL474843 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL480545 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL480383 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL480382 | GSK-312948A | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL519120 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL475763 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL474054 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL475783 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL514634 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL474029 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL514968 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL514826 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL520080 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL473630 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL475616 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL481510 | GW853606X | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL475215 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL474432 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL516362 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL514643 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL519286 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL475762 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL473629 | GSK-204925A | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL481492 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL519289 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL219899 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL482349 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL480371 | GW853609X | IC50 | > | 30000.0 | nM | - |
| CHEMBL482151 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL520284 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL514040 | — | IC50 | > | 30000.0 | nM | - |