Assay Detail
Functional
CHEMBL941603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 infected in mouse macrophage by reporter dye assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.07 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.25 |
| CHEMBL515337 | — | — | 1 | 6.40 |
| CHEMBL515026 | — | — | 1 | 6.31 |
| CHEMBL478498 | — | — | 1 | 6.19 |
| CHEMBL479007 | — | — | 1 | 6.15 |
| CHEMBL516902 | — | — | 1 | 6.15 |
| CHEMBL477491 | — | — | 1 | 5.84 |
| CHEMBL478170 | — | — | 1 | 5.74 |
| CHEMBL518446 | — | — | 1 | 5.69 |
| CHEMBL478169 | — | — | 1 | 5.51 |
| CHEMBL479195 | — | — | 1 | 5.38 |
| CHEMBL478289 | — | — | 1 | 5.26 |
| CHEMBL478541 | — | — | 1 | 5.19 |
| CHEMBL518756 | — | — | 1 | 5.14 |
| CHEMBL475085 | — | — | 1 | 5.10 |
| CHEMBL477288 | — | — | 1 | 5.07 |
| CHEMBL477280 | — | — | 1 | 4.95 |
| CHEMBL478542 | — | — | 1 | 4.85 |
| CHEMBL503217 | — | — | 1 | 4.76 |
| CHEMBL479200 | — | — | 1 | 4.73 |
| CHEMBL514009 | — | — | 1 | 4.70 |
| CHEMBL478525 | — | — | 1 | 4.68 |
| CHEMBL507999 | — | — | 1 | 4.62 |
| CHEMBL502204 | — | — | 1 | 4.60 |
| CHEMBL510005 | — | — | 1 | 4.58 |
| CHEMBL474280 | — | — | 1 | 4.57 |
| CHEMBL478153 | — | — | 1 | 4.57 |
| CHEMBL445822 | — | — | 1 | 4.56 |
| CHEMBL478911 | — | — | 1 | 4.53 |
| CHEMBL478371 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL515337 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL515026 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL478498 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL479007 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL516902 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL477491 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL478170 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL518446 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL478169 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL479195 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL478289 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL478541 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL518756 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL475085 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL477288 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL477280 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL478542 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL503217 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL479200 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL514009 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL478525 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL507999 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL502204 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL510005 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL474280 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL478153 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL445822 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL478911 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL478371 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL477281 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL515019 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL477500 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL516107 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL500770 | — | IC50 | = | 71500.0 | nM | 4.15 |
| CHEMBL515650 | — | IC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL478367 | — | IC50 | = | 83300.0 | nM | 4.08 |
| CHEMBL477682 | — | IC50 | = | 87200.0 | nM | 4.06 |
| CHEMBL479222 | — | IC50 | = | 172000.0 | nM | - |