Assay Detail
Binding
CHEMBL941668
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Inhibition of human thrombin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.91 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554926 | — | — | 1 | 5.20 |
| CHEMBL399331 | — | — | 1 | 4.82 |
| CHEMBL248725 | — | — | 1 | 4.72 |
| CHEMBL248724 | — | — | 1 | - |
| CHEMBL399330 | — | — | 1 | - |
| CHEMBL250985 | — | — | 1 | - |
| CHEMBL398518 | — | — | 1 | - |
| CHEMBL398517 | — | — | 1 | - |
| CHEMBL398516 | — | — | 1 | - |
| CHEMBL399956 | — | — | 1 | - |
| CHEMBL251762 | — | — | 1 | - |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554926 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL399331 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL248725 | — | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL248724 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL399330 | — | Ki | > | 6300.0 | nM | - |
| CHEMBL250985 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL398518 | — | Ki | > | 6300.0 | nM | - |
| CHEMBL398517 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL398516 | — | Ki | > | 6300.0 | nM | - |
| CHEMBL399956 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL251762 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL206335 | RAZAXABAN | Ki | > | 6300.0 | nM | - |