Assay Detail

CHEMBL941722

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Functional

Induction of proliferation of human CD34+ cells by CFUMEG colony assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CD34+ cell
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Pyrimidine benzamide-based thrombopoietin receptor agonists.

Reiter LA, Subramanyam C, Mangual EJ, Jones CS, Smeets MI, Brissette WH, McCurdy SP, Lira PD, Linde RG, Li Q, Zhang F, Antipas AS, Blumberg LC, Doty JL, Driscoll JP, Munchhof MJ, Ripp SL, Shavnya A, Shepard RM, Sperger D, Thomasco LM, Trevena KA, Wolf-Gouveia LA, Zhang L.
Bioorg Med Chem Lett (2007) 17 : 5447 -5454
PubMed 17707640 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.68	6.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL248217	—	—	1	6.89
CHEMBL428226	—	—	1	6.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL248217	—	EC50	=	130.0	nM	6.89
CHEMBL428226	—	EC50	=	340.0	nM	6.47