Assay Detail
Binding
CHEMBL942005
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Binding affinity to glucocorticoid receptor in SW1353 cells by whole-cell binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.93 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.09 |
| CHEMBL78625 | — | — | 1 | 8.26 |
| CHEMBL250700 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL78625 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL250700 | — | Ki | = | 352.0 | nM | 6.45 |