Assay Detail
Functional
CHEMBL942574
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Antiviral activity against Vaccinia virus infected in human foreskin fibroblasts by plaque assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of vidarabine prodrugs as antiviral agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.48 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474055 | — | — | 1 | 5.75 |
| CHEMBL475036 | — | — | 1 | 5.64 |
| CHEMBL475233 | — | — | 1 | 5.60 |
| CHEMBL474852 | — | — | 1 | 5.54 |
| CHEMBL474030 | — | — | 1 | 5.52 |
| CHEMBL475206 | — | — | 1 | 5.48 |
| CHEMBL475234 | — | — | 1 | 5.46 |
| CHEMBL475035 | — | — | 1 | 5.39 |
| CHEMBL515278 | — | — | 1 | 5.35 |
| CHEMBL511024 | — | — | 1 | 5.32 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474055 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL475036 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL475233 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL474852 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL474030 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL475206 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL475234 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL475035 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL515278 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL511024 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1090 | VIDARABINE | EC50 | = | 6200.0 | nM | 5.21 |