Assay Detail
Functional
CHEMBL942712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell cycle arrest in H1299 cells by accumulation at G2/M phase by FACS assay
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.58 | 5.58 |
| Activity | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248555 | — | — | 1 | 5.58 |
| CHEMBL398757 | — | — | 1 | - |
| CHEMBL249156 | — | — | 1 | - |
| CHEMBL249364 | — | — | 1 | - |
| CHEMBL375097 | — | — | 1 | - |
| CHEMBL249363 | — | — | 1 | - |
| CHEMBL400575 | — | — | 1 | - |
| CHEMBL248951 | — | — | 1 | - |
| CHEMBL400804 | — | — | 1 | - |
| CHEMBL248953 | — | — | 1 | - |
| CHEMBL400805 | — | — | 1 | - |
| CHEMBL249154 | — | — | 1 | - |
| CHEMBL400806 | — | — | 1 | - |
| CHEMBL401196 | — | — | 1 | - |
| CHEMBL248757 | — | — | 1 | - |
| CHEMBL250375 | — | — | 1 | - |
| CHEMBL400693 | — | — | 1 | - |
| CHEMBL249764 | — | — | 1 | - |
| CHEMBL249765 | — | — | 1 | - |
| CHEMBL249971 | — | — | 1 | - |
| CHEMBL398875 | — | — | 1 | - |
| CHEMBL437772 | — | — | 1 | - |
| CHEMBL250173 | — | — | 1 | - |
| CHEMBL400668 | — | — | 1 | - |
| CHEMBL399916 | — | — | 1 | - |
| CHEMBL401337 | — | — | 1 | - |
| CHEMBL248553 | — | — | 1 | - |
| CHEMBL400397 | — | — | 1 | - |
| CHEMBL248554 | — | — | 1 | - |
| CHEMBL249972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248555 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL249363 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL400806 | — | Activity | - | — | - | |
| CHEMBL249154 | — | Activity | - | — | - | |
| CHEMBL400805 | — | Activity | - | — | - | |
| CHEMBL248953 | — | Activity | - | — | - | |
| CHEMBL400804 | — | Activity | - | — | - | |
| CHEMBL248951 | — | Activity | - | — | - | |
| CHEMBL400575 | — | Activity | - | — | - | |
| CHEMBL248757 | — | Activity | - | — | - | |
| CHEMBL375097 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249364 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249156 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249155 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248952 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248756 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248755 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL400574 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL437772 | — | Activity | - | — | - | |
| CHEMBL249972 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248554 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL400397 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248553 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL401337 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL399916 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL400668 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL250173 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL401196 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL398875 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249971 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249765 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249764 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL400693 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL398757 | — | Activity | - | — | - | |
| CHEMBL250375 | — | Activity | - | — | - |