Assay Detail
Binding
CHEMBL943607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KIT by fluorescence polarization competition immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.01 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492809 | — | — | 1 | 8.22 |
| CHEMBL505830 | — | — | 1 | 8.22 |
| CHEMBL452965 | — | — | 1 | 7.89 |
| CHEMBL403776 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492809 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL505830 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL452965 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403776 | — | IC50 | = | 20.0 | nM | 7.70 |