Assay Detail
Binding
CHEMBL943610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TrkA by fluorescence polarization competition immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.54 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403776 | — | — | 1 | 6.77 |
| CHEMBL492809 | — | — | 1 | 6.30 |
| CHEMBL505830 | — | — | 1 | - |
| CHEMBL452965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403776 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL492809 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL505830 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL452965 | — | IC50 | > | 500.0 | nM | - |