Assay Detail
Binding
CHEMBL944009
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Inhibition of human Hsp90-alpha by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.78 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.70 |
| CHEMBL404630 | — | — | 1 | 7.52 |
| CHEMBL254875 | — | — | 1 | 7.40 |
| CHEMBL362307 | — | — | 1 | 7.22 |
| CHEMBL361078 | — | — | 1 | 6.72 |
| CHEMBL402712 | — | — | 1 | 6.10 |
| CHEMBL360410 | — | — | 1 | 4.82 |
| CHEMBL254876 | — | — | 1 | - |
| CHEMBL254874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL404630 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL254875 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL362307 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL361078 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL402712 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL360410 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL254876 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254874 | — | IC50 | > | 20000.0 | nM | - |