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Assay Detail

CHEMBL944036

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Binding
Inhibition of MMP1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A novel series of highly selective inhibitors of MMP-3.
Whitlock GA, Dack KN, Dickinson RP, Lewis ML.
Bioorg Med Chem Lett (2007) 17 : 6750 -6753
PubMed 18029177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.17 5.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL398641 1 5.49
CHEMBL251917 1 4.85
CHEMBL250266 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL398641 IC50 = 3230.0 nM 5.49
CHEMBL251917 IC50 = 14000.0 nM 4.85
CHEMBL250266 IC50 > 100000.0 nM -