Assay Detail
Binding
CHEMBL944160
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Displacement of [3H]SCH-23390 from rat dopamine D1 receptor
72
Total Activities
69
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Advances in development of dopaminergic aporphinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 47 | 5.90 | 8.70 |
| IC50 | 25 | 5.61 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256075 | — | — | 1 | 8.70 |
| CHEMBL401690 | — | — | 1 | 8.22 |
| CHEMBL401689 | — | — | 1 | 7.82 |
| CHEMBL225853 | 3-BROMOBOLDINE | — | 1 | 7.31 |
| CHEMBL452776 | CELTISINE | — | 1 | 7.22 |
| CHEMBL452510 | BREOGANINE | — | 1 | 7.00 |
| CHEMBL119455 | — | — | 1 | 6.96 |
| CHEMBL155884 | — | — | 1 | 6.77 |
| CHEMBL404137 | — | — | 1 | 6.77 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.68 |
| CHEMBL404136 | PREDICENTRINE | — | 1 | 6.62 |
| CHEMBL118254 | — | — | 1 | 6.57 |
| CHEMBL388342 | BOLDINE | — | 2 | 6.54 |
| CHEMBL53510 | — | — | 1 | 6.42 |
| CHEMBL258370 | PUKATEINE | — | 1 | 6.40 |
| CHEMBL403032 | — | — | 1 | 6.28 |
| CHEMBL27559 | — | — | 1 | 6.16 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.14 |
| CHEMBL157912 | (S)-BULBOCAPNINE | — | 1 | 6.13 |
| CHEMBL258372 | — | — | 1 | 6.10 |
| CHEMBL455633 | CULARIDINE | — | 1 | 6.10 |
| CHEMBL288096 | — | — | 2 | 6.04 |
| CHEMBL322574 | — | — | 1 | 6.01 |
| CHEMBL452512 | CLAVICULINE | — | 1 | 6.00 |
| CHEMBL332332 | — | — | 1 | 5.96 |
| CHEMBL106622 | — | — | 1 | 5.89 |
| CHEMBL283489 | — | — | 1 | 5.85 |
| CHEMBL53294 | — | — | 2 | 5.75 |
| CHEMBL119593 | — | — | 1 | 5.70 |
| CHEMBL401567 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256075 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL401690 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL401689 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL225853 | 3-BROMOBOLDINE | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL452776 | CELTISINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL452510 | BREOGANINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL119455 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL155884 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL404137 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL53 | APOMORPHINE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL404136 | PREDICENTRINE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL118254 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL388342 | BOLDINE | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL53510 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL258370 | PUKATEINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL388342 | BOLDINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL403032 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL27559 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL157912 | (S)-BULBOCAPNINE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL258372 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL455633 | CULARIDINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL288096 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL322574 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL452512 | CLAVICULINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL332332 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL106622 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL283489 | — | Ki | = | 1413.0 | nM | 5.85 |
| CHEMBL288096 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL53294 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL119593 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL401567 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL487388 | NORBOLDINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL228082 | GLAUCINE | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL155208 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL53294 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL439639 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL253530 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL254147 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL257745 | NORSTEPHALAGINE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL155352 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL253738 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL402736 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL404865 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL253736 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL154468 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL404240 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL253947 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL402735 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL508011 | ISOPILINE | IC50 | = | 9800.0 | nM | 5.01 |