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Assay Detail

CHEMBL944268

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Binding
Inhibition of Plasmodium falciparum KAS3 expressed in Escherichia coli assessed as transfer of [1-14C]acetyl-CoA to [1-14C]acetyl-ACP
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.
Lee PJ, Bhonsle JB, Gaona HW, Huddler DP, Heady TN, Kreishman-Deitrick M, Bhattacharjee A, McCalmont WF, Gerena L, Lopez-Sanchez M, Roncal NE, Hudson TH, Johnson JD, Prigge ST, Waters NC.
J Med Chem (2009) 52 : 952 -963
PubMed 19191586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 5.60 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL490686 — — 1 6.89
CHEMBL472940 — — 1 6.89
CHEMBL510173 — — 1 6.85
CHEMBL514770 — — 1 6.62
CHEMBL489497 — — 1 6.62
CHEMBL446646 — — 1 6.55
CHEMBL489905 — — 1 6.50
CHEMBL509952 — — 1 6.42
CHEMBL522958 — — 1 6.36
CHEMBL501847 — — 1 6.30
CHEMBL473135 — — 1 6.28
CHEMBL499767 — — 1 6.28
CHEMBL472941 — — 1 6.20
CHEMBL462861 — — 1 6.19
CHEMBL509279 — — 1 5.85
CHEMBL489505 — — 1 5.82
CHEMBL405015 — — 1 5.72
CHEMBL473138 — — 1 5.66
CHEMBL473534 — — 1 5.55
CHEMBL473535 FENTICLOR 2.0 1 5.51
CHEMBL521919 — — 1 5.50
CHEMBL489496 — — 1 5.31
CHEMBL472738 — — 1 5.30
CHEMBL501281 — — 1 5.28
CHEMBL473536 — — 1 4.97
CHEMBL6967 — — 1 4.74
CHEMBL489105 — — 1 4.66
CHEMBL491675 — — 1 4.65
CHEMBL489498 — — 1 4.59
CHEMBL454221 — — 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL490686 — IC50 = 130.0 nM 6.89
CHEMBL472940 — IC50 = 130.0 nM 6.89
CHEMBL510173 — IC50 = 140.0 nM 6.85
CHEMBL514770 — IC50 = 240.0 nM 6.62
CHEMBL489497 — IC50 = 240.0 nM 6.62
CHEMBL446646 — IC50 = 280.0 nM 6.55
CHEMBL489905 — IC50 = 320.0 nM 6.50
CHEMBL509952 — IC50 = 380.0 nM 6.42
CHEMBL522958 — IC50 = 440.0 nM 6.36
CHEMBL501847 — IC50 = 500.0 nM 6.30
CHEMBL473135 — IC50 = 530.0 nM 6.28
CHEMBL499767 — IC50 = 520.0 nM 6.28
CHEMBL472941 — IC50 = 630.0 nM 6.20
CHEMBL462861 — IC50 = 650.0 nM 6.19
CHEMBL509279 — IC50 = 1400.0 nM 5.85
CHEMBL489505 — IC50 = 1500.0 nM 5.82
CHEMBL405015 — IC50 = 1900.0 nM 5.72
CHEMBL473138 — IC50 = 2200.0 nM 5.66
CHEMBL473534 — IC50 = 2800.0 nM 5.55
CHEMBL473535 FENTICLOR IC50 = 3100.0 nM 5.51
CHEMBL521919 — IC50 = 3200.0 nM 5.50
CHEMBL489496 — IC50 = 4900.0 nM 5.31
CHEMBL472738 — IC50 = 5000.0 nM 5.30
CHEMBL501281 — IC50 = 5200.0 nM 5.28
CHEMBL473536 — IC50 = 10800.0 nM 4.97
CHEMBL6967 — IC50 = 18300.0 nM 4.74
CHEMBL489105 — IC50 = 22000.0 nM 4.66
CHEMBL491675 — IC50 = 22500.0 nM 4.65
CHEMBL489498 — IC50 = 25800.0 nM 4.59
CHEMBL454221 — IC50 = 27200.0 nM 4.57
CHEMBL490099 — IC50 = 38200.0 nM 4.42
CHEMBL524094 — IC50 = 48100.0 nM 4.32
CHEMBL462553 — IC50 = 53700.0 nM 4.27
CHEMBL489904 — IC50 = 62900.0 nM 4.20
CHEMBL449180 — IC50 = 63800.0 nM 4.20
CHEMBL399043 THIOLACTOMYCIN IC50 > 330000.0 nM -
CHEMBL489703 — IC50 = 447700.0 nM -
CHEMBL473137 — IC50 = 195200.0 nM -
CHEMBL1539 SULFADOXINE IC50 > 1000000.0 nM -
CHEMBL490100 — IC50 = 164600.0 nM -
CHEMBL473339 — IC50 > 1000000.0 nM -
CHEMBL489104 — IC50 = 114600.0 nM -
CHEMBL462375 — IC50 = 192600.0 nM -
CHEMBL453261 — IC50 = 157500.0 nM -