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Assay Detail

CHEMBL944276

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant EGFR
ChEMBL ↗
181
Total Activities
180
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Epidermal growth factor receptor (CHEMBL203) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies.
La Motta C, Sartini S, Tuccinardi T, Nerini E, Da Settimo F, Martinelli A.
J Med Chem (2009) 52 : 964 -975
PubMed 19170633 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 181 8.15 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53428 — — 1 10.05
CHEMBL54400 — — 1 9.89
CHEMBL490496 — — 1 9.80
CHEMBL491083 — — 1 9.77
CHEMBL127041 — — 1 9.62
CHEMBL443523 — — 2 9.60
CHEMBL128468 — — 1 9.55
CHEMBL510396 — — 1 9.43
CHEMBL39320 — — 1 9.43
CHEMBL522134 — — 1 9.38
CHEMBL474147 — — 1 9.38
CHEMBL336264 — — 1 9.37
CHEMBL461797 — — 1 9.36
CHEMBL39337 — — 1 9.36
CHEMBL447331 — — 1 9.36
CHEMBL447850 — — 1 9.35
CHEMBL516022 — — 1 9.32
CHEMBL501618 — — 1 9.30
CHEMBL126791 — — 1 9.29
CHEMBL446019 — — 1 9.27
CHEMBL491085 — — 1 9.26
CHEMBL460723 — — 1 9.25
CHEMBL138940 — — 1 9.22
CHEMBL127086 — — 1 9.22
CHEMBL511874 — — 1 9.17
CHEMBL521571 — — 1 9.16
CHEMBL522623 — — 1 9.16
CHEMBL454383 — — 1 9.15
CHEMBL460721 — — 1 9.14
CHEMBL474141 — — 1 9.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53428 — IC50 = 0.08913 nM 10.05
CHEMBL54400 — IC50 = 0.1288 nM 9.89
CHEMBL490496 — IC50 = 0.1585 nM 9.80
CHEMBL491083 — IC50 = 0.1698 nM 9.77
CHEMBL127041 — IC50 = 0.2399 nM 9.62
CHEMBL443523 — IC50 = 0.2512 nM 9.60
CHEMBL128468 — IC50 = 0.2818 nM 9.55
CHEMBL510396 — IC50 = 0.3715 nM 9.43
CHEMBL39320 — IC50 = 0.3715 nM 9.43
CHEMBL522134 — IC50 = 0.4169 nM 9.38
CHEMBL474147 — IC50 = 0.4169 nM 9.38
CHEMBL336264 — IC50 = 0.4266 nM 9.37
CHEMBL447331 — IC50 = 0.4365 nM 9.36
CHEMBL39337 — IC50 = 0.4365 nM 9.36
CHEMBL461797 — IC50 = 0.4365 nM 9.36
CHEMBL447850 — IC50 = 0.4467 nM 9.35
CHEMBL443523 — IC50 = 0.4467 nM 9.35
CHEMBL516022 — IC50 = 0.4786 nM 9.32
CHEMBL501618 — IC50 = 0.5012 nM 9.30
CHEMBL126791 — IC50 = 0.5129 nM 9.29
CHEMBL446019 — IC50 = 0.537 nM 9.27
CHEMBL491085 — IC50 = 0.5495 nM 9.26
CHEMBL460723 — IC50 = 0.5623 nM 9.25
CHEMBL138940 — IC50 = 0.6026 nM 9.22
CHEMBL127086 — IC50 = 0.6026 nM 9.22
CHEMBL511874 — IC50 = 0.6761 nM 9.17
CHEMBL522623 — IC50 = 0.6918 nM 9.16
CHEMBL521571 — IC50 = 0.6918 nM 9.16
CHEMBL454383 — IC50 = 0.7079 nM 9.15
CHEMBL474141 — IC50 = 0.7244 nM 9.14
CHEMBL460721 — IC50 = 0.7244 nM 9.14
CHEMBL289213 — IC50 = 0.7244 nM 9.14
CHEMBL339416 — IC50 = 0.7413 nM 9.13
CHEMBL524117 — IC50 = 0.7586 nM 9.12
CHEMBL447223 — IC50 = 0.7586 nM 9.12
CHEMBL139095 — IC50 = 0.7586 nM 9.12
CHEMBL516373 — IC50 = 0.7762 nM 9.11
CHEMBL491676 — IC50 = 0.7762 nM 9.11
CHEMBL489112 — IC50 = 0.7943 nM 9.10
CHEMBL460722 — IC50 = 0.8128 nM 9.09
CHEMBL524115 — IC50 = 0.912 nM 9.04
CHEMBL126372 — IC50 = 0.912 nM 9.04
CHEMBL338114 — IC50 = 0.912 nM 9.04
CHEMBL474342 — IC50 = 0.912 nM 9.04
CHEMBL490497 — IC50 = 0.955 nM 9.02
CHEMBL490498 — IC50 = 0.9772 nM 9.01
CHEMBL460743 — IC50 = 1.096 nM 8.96
CHEMBL474142 — IC50 = 1.096 nM 8.96
CHEMBL454370 — IC50 = 1.096 nM 8.96
CHEMBL127058 — IC50 = 1.202 nM 8.92