Assay Detail
Functional
CHEMBL944462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor (CHEMBL1793) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.54 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526530 | — | — | 1 | 10.22 |
| CHEMBL506126 | — | — | 1 | 9.82 |
| CHEMBL526677 | — | — | 1 | 9.04 |
| CHEMBL525069 | — | — | 1 | 8.96 |
| CHEMBL450474 | — | — | 1 | 7.89 |
| CHEMBL499651 | — | — | 1 | 7.58 |
| CHEMBL514849 | — | — | 1 | 7.50 |
| CHEMBL505612 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526530 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL506126 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL526677 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL525069 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL450474 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL499651 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL514849 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL505612 | — | EC50 | = | 53.0 | nM | 7.28 |