Compound Detail
CHEMBL499651
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CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL499651 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | UPWWBYZXEMNPPN-AZNRRKNOSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1839.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.58
IC50 1 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL1793 | EC50 | 7.58 | 6.71 | 26.0 | 2 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL6038 | EC50 | 6.89 | 6.89 | 129.0 | 1 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL1793 | IC50 | 5.66 | 5.66 | 2187.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17428923 | 10.1073/pnas.0605125104 | Parathyroid hormone/parathyroid hormone-related peptide receptor | 4 |
Data from ChEMBL 36 via Core Engine